Abnormal Sleep Signals Vulnerability to Chronic Social Defeat Stress

There is a tight association between mood and sleep as disrupted core feature of many disorders. The paucity in available animal models for investigating the role etiopathogenesis depression-like behaviors led us to investigate whether prior disturbances can predict susceptibility future stress. Hence, we assessed before after chronic social defeat (CSD) behavior mice post stress was classified two main phenotypes: susceptible that displayed avoidance resilient Pre-CSD, increased fragmentation Non-Rapid Eye Movement (NREM) sleep, due switching NREM wake shorter average duration bouts, relative Logistic regression analysis showed pre-CSD features from both phenotypes were separable enough allow prediction with >80% accuracy. Post-CSD, maintained high while exhibited fragmentation, only dark. Our findings emphasize putative fragmented signaling vulnerability